INFECTION AND TRANSFORMATION OF MOUSE PERITONEAL MACROPHAGES BY SIMIAN VIRUS 40
نویسندگان
چکیده
منابع مشابه
Infection and Transformation of Mouse Peritoneal Macrophages by Simian Virus 40
The stimulation of DNA synthesis in mouse (C57BL) macrophages explanted in vitro was demonstrated after treatment with conditioned medium or infection with SV40. In the latter case, induction of SV40 T antigen was detected before TdR-(3)H incorporation. Even though all macrophages were infected (T antigen-positive), they exhibited considerable pleomorphism, accompanied by functional differences...
متن کاملTransformation of human skeletal muscle cells by simian virus 40.
Molecular studies of the biochemical alterations involved in human myopathies have been restricted because of the finite life-span and slow growth rate of cultures derived from primary tissue. Because the tumor virus simian virus 40 (SV40) can alter both the growth properties and longevity of human cells, we have infected skeletal muscle cultures derived from four biopsies with a small-plaque v...
متن کاملSusceptibility of human cell strains to transformation by simian virus 40 and simian virus 40 deoxyribonucleic acid.
Marked differences were found in the susceptibility of human fibroblasts to transformation by simian virus 40 (SV40). Highly susceptible cell strains were derived from patients with diseases associated with chromosomal abnormalities and a high incidence of tumors. In the present study, SV40 transformation-susceptible cell strains were not found to have a generalized increase in viral sensitivit...
متن کاملSimian virus 40 gene A function and maintenance of transformation.
Transformants have been isolated after infection of rat embryo cells at 33 C with either wild-type simian virus 40 or with the temperature-sensitive gene A mutants, tsA7 and tsA28. Examination of properties usually associated with transformation such as growth in 1% serum, growth rate, saturation density, and morphology show that these properties are temperature dependent in the tsA transforman...
متن کاملSimian virus 40 infection is not mediated by lysosomal activation.
The uptake of simian virus 40 (SV40) virions to the nucleus, the site of viral replication, proceeds via engulfment at the cytoplasmic membrane and transport in monopinocytotic vesicles through the cytoplasm to the nuclear membrane. In the case of Semliki Forest virus and poliovirus which undergo primary endocytosis in a similar manner, neutralization of the acid pH in these vesicles abolishes ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1971
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.134.2.335